Cost-Effective Method to Investigate Activity and Anxiety in Zebrafish Larvae

I develop a new method that is easily reproducible to perform the light/dark test in zebrafish larvae using simple infrared camera. This can be used by any research facility at low cost and investigate neurological disorders.

Elucidating the role of Amyloid Precursor Protein (APP) in neurodegeneration

Using cell and mice models, we elucidate a new role of APP in sensing damaged DNA from the nucleus, binding and exporting them into the extracellular space upon DNA damage.

The role of environmental context in Ube3a mutant zebrafish

Zebrafish mutants in ube3a demonstrate increased anxiety and freezing behaviors when subjected to social interaction with their peer. We believe autism might be related to abnormal signaling and processing of visual information.

Prenatal nicotine exposure lead to ADHD in mice and zebrafish!

In this project, I use zebrafish and mice subjected to nicotine exposure. The offspring developed ADHD-like behaviors and primary cilia defects.

FMR1 KO in zebrafish causes autism-like behaviors in zebrafish

We KO fmr1 in zebrafish and they displayed behaviors similar to autism. We also conducted molecular and functional analysis of the fmr1 deletion in zebrafish.

Sedative, anxiolytic and antidepressant effects of essential oils from the leaves of natural plants

During my PhD, I investigate 3 plants species for their sedative, anxiolytic and antidepressant activities in mice. These can be used to further investigate brain-related disorderss like ADHD, autism, PTSD.