Lipofuscin accumulation in aging and neurodegeneration: a potential “timebomb” overlooked in Alzheimer’s disease
Lipofuscin, a marker of aging, is the accumulation of autofluorescent granules within microglia and postmitotic cells such as neurons. Lipofuscin has traditionally been regarded as an inert byproduct of cellular degradation. However, recent findings su... (Link)
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New Paper in Translational Psychiatry!!! We love the good job!!!
Angelman syndrome and Fragile X syndrome are neurodevelopmental disorders (NDDs) caused by mutations in the UBE3A and FMR1 genes, respectively. However, they share common features such as cognitive and motor deficits, anxiety, and impaired social behav... (Link)
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Press Release
Japanese version University HP https://www.bri.niigata-u.ac.jp/research/result/002346.html X https://x.com/niigata_nouken/status/1963837182575259870 English version University HP https://www.bri.niigata-u.ac.jp/en/research/result/002347.html X ... (Link)
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New paper in Molecular Psychiatry was accepted!!!
Individuals with autism spectrum disorder (ASD) have a greater prevalence of deficits in social interactions and repetitive behaviours, which are influenced by hereditary and environmental factors. How environmental factors influence genetically predi... (Link)
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New Paper in Aging Brain
Manuscript was accepted for publication. (Link)
48th Annual Meeting of the Japanese Neuroscience Society
I was co-chair (oral presentation on Neurodegenerative disorders) at the 48th Annual Meeting of the Japanese Neuroscience Society and delivered a Poster presentation about the mechanisms of zebrafish ube3a in social behavior in autism. (Link)
New paper in Frontiers in Psychiatry
Attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorders (ASD) are two increasingly prevalent neurodevelopmental disorders (NDDs), often accompanied by significant daily-life challenges. Animal models play a crucial role in studyin... (Link)
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New grant for the ube3a mutants
My work on ube3a zebrafish mutants has been awarded the Niigata University Tsukada Medical Scholarship Fund.
Interview at BRI (Young scientists)
I did an interview for the BRI